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Stephen J Medhurst Selected Research

1- (1- methylethyl)- 4- ((1- (6- (trifluoromethyl)- 3- pyridinyl)- 4- piperidinyl)carbonyl)hexahydro- 1H- 1,4- diazepine

8/2008Novel histamine H3 receptor antagonists GSK189254 and GSK334429 are efficacious in surgically-induced and virally-induced rat models of neuropathic pain.
4/2007Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats.

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Stephen J Medhurst Research Topics

Disease

5Pain (Aches)
09/2010 - 12/2002
5Hyperalgesia
07/2008 - 12/2002
3Neuralgia (Stump Neuralgia)
08/2008 - 01/2003
2Hypersensitivity (Allergy)
08/2008 - 12/2005
1Amnesia (Dissociative Amnesia)
04/2007
1Dementia (Dementias)
04/2007
1Arthralgia (Joint Pain)
08/2006
1Cancer Pain
12/2002
1Inflammation (Inflammations)
12/2002
1Neoplasm Metastasis (Metastasis)
12/2002
1Bone Neoplasms (Bone Cancer)
12/2002
1Peripheral Nervous System Diseases (PNS Diseases)
12/2002

Drug/Important Bio-Agent (IBA)

2Freund's AdjuvantIBA
08/2010 - 07/2008
21- (1- methylethyl)- 4- ((1- (6- (trifluoromethyl)- 3- pyridinyl)- 4- piperidinyl)carbonyl)hexahydro- 1H- 1,4- diazepineIBA
08/2008 - 04/2007
2Histamine H3 AntagonistsIBA
08/2008 - 04/2007
2Capsaicin (Zostrix)FDA Link
04/2007 - 01/2003
1Pyrrolidonecarboxylic Acid (Pyroglutamic Acid)IBA
09/2010
1AmidesIBA
09/2010
1Histamine (Histamine Dihydrochloride)FDA Link
08/2008
16- ((3- cyclobutyl- 2,3,4,5- tetrahydro- 1H- 3- benzazepin- 7- yl)oxy)- N- methyl- 3- pyridinecarboxamideIBA
08/2008
1Niacinamide (Nicotinamide)FDA LinkGeneric
08/2008
1Cholinergic ReceptorsIBA
07/2008
1Scopolamine (Hyoscine)FDA Link
04/2007
15- ((3- cyclobutyl- 2,3,4,5- tetrahydro- 1H- 3- benzazepin- 7- yl)oxy)- N- methyl- 2- pyrazinecarboxamideIBA
04/2007
1Cholinergic Antagonists (Anticholinergics)IBA
04/2007
1Cannabinoid Receptor AgonistsIBA
12/2005
11,1-dimethylbutyl-1-deoxy-Delta(9)-THCIBA
12/2005
1HU 211 (HU 210)IBA
12/2005
1CB2 Cannabinoid ReceptorIBA
12/2005
1CarrageenanIBA
12/2005
1CannabinoidsIBA
12/2005
1capsazepineIBA
01/2003
1Celecoxib (Celebrex)FDA Link
12/2002
1Therapeutic UsesIBA
12/2002
1Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
12/2002
1Diphosphonates (Bisphosphonates)IBA
12/2002
1Pharmaceutical PreparationsIBA
12/2002
1Clodronic Acid (Clodronate)IBA
12/2002
1Pamidronate (Aredia)FDA LinkGeneric
12/2002
1Zoledronic Acid (Zometa)FDA Link
12/2002

Therapy/Procedure

1Oral Administration
08/2008
1Therapeutics
08/2006
1Ligation
01/2003